 | Brittany Murphy | ... | Alice |
 | Thora Birch | ... | Lucy |
 | Tammy Blanchard | ... | Rebecca |
 | Marc Blucas | ... | David |
 | Claudia Troll | ... | David's Mother |
| Michael Piscitelli | ... | Ben's Voice (voice) |
 | Big Daddy Kane | ... | Hunter |
 | Brandon Hardin | ... | Ski |
| D.J. Naylor | ... | Ackson |
| Dominic L. Santana | ... | Malcolm |
| E-40 | ... | Hustle |
 | Traci Dinwiddie | ... | Kate (as T-Love) |
| Michael Braxton | ... | Trey |
| Chris Bailey | ... | Bone |
 | Bone Crusher | ... | Himself (as Bonecrusher) |
 | Zach Hanner | ... | Rich |
| Jon Stafford | ... | Sheriff |
 | Bill Ladd | ... | Deputy Miller |
 | Cullen Moss | ... | Deputy ... |
| Charlie Lucas | ... | Uncle Authur |
| Joi Heggins | ... | Bonecrusher's Girl |
| Jerrelle Anderson | ... | Cotton |
 | General Fermon Judd Jr. | ... | Mike (as Furman Judd) |
| Courtney Lenz | ... | Kelly |
| Chantel Liddel | ... | Waitress |
| Windy Wenderlich | ... | Bank Security Guard |
| Robert Johnson | ... | Bartender |
| Patti Briscoe | ... | Bank Teller |
| Mark Robinson | ... | Roadside Zombie |
 | Taylor Kowalski | ... | Gas Station Zombie |
| Micah 'Checka' Noble | ... | Gas Station Zombie |
| Steve Bass | ... | Basement zombie |
| Michelle Mims | ... | Becky |
| Cherish Lee | ... | Rachel |
 | Brent Fidler | ... | Dr. Brown |
| Benjamin Pitts | ... | Liam |
 | Nick Mathis | ... | Nick |
 | Rebekah Brandes | ... | Katie |
| Turiya Dawn | ... | Tia |
 | Peter Bisson | ... | Pete |
 | Mike Korich | ... | Stuart |
| Adam Fortin | ... | Grim Reaper |
 | James C. Burns | ... | Homeless Man |
 | Caia Coley | ... | Karen |
| Jay Wilkins | ... | Paramedic |
 | Serdar Kalsin | ... | Cab Driver |
 | Alice Ensor | ... | Nurse Hill |
| J.D. Head | ... | Bubba |
